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Effectiveness of interventions to improve screening for syphilis in pregnancy: a systematic review and meta-analysis

Hawkes,S et al.; Lancet Infectious Diseases, 2011; 11: 684-691.

Background: About 2·1 million pregnant women have active syphilis every year. Without screening and treatment, [...]
Effectiveness of interventions to improve screening for syphilis in pregnancy: a systematic review and meta-analysis

Hawkes,S et al.; Lancet Infectious Diseases, 2011; 11: 684-691.

Background: About 2·1 million pregnant women have active syphilis every year. Without screening and treatment, 69% of these women will have an adverse outcome of pregnancy. The objectives of this study were to review the literature systematically to determine the effectiveness of screening interventions to prevent congenital syphilis and other adverse pregnancy outcomes.

Interpretation: Interventions to improve the coverage and effect of screening programmes for antenatal syphilis could reduce the syphilis-attributable incidence of stillbirth and perinatal death by 50%. The resources required to roll out antenatal screening programmes would be a worthwhile investment for reduction of adverse pregnancy outcomes and improvement of neonatal and child survival.
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